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Sang-Hun Lee, PhD

Sanghun PhotoIn August 2015, Sang-Hun Lee, Ph.D., joined the Department of Neurology as an Assistant Professor. Dr. Lee obtained his Ph.D. in physiology from the University of Illinois at Urbana-Champaign, USA, and then underwent postdoctoral training at the University of California Irvine, USA. During his Ph.D. and postdoctoral training, he studied basic neurobiology questions, epilepsy, and radiation neurobiology and published numerous research and review articles in highly respected neuroscience journals (e.g., Nature Reviews Neuroscience, Nature Neuroscience, Neuron, Trends in Neurosciences, and Journal of Neuroscience). He is an active member of professional organizations, including the Society for Neuroscience and Radiation Research Society.

Dr. Lee’s research team studies the functional organization of GABAergic inhibitory circuits in hippocampal networks which regulate neural activity in normal and pathological conditions. His team focuses on the hippocampal cannabinoid signaling system, because hippocampal GABAergic inhibitory activity is regulated by the cannabinoid signaling system, and abnormal cannabinoid signaling in the brain may be mechanistically connected to certain pathological conditions, such as epilepsy. His team employs state-of-the-art techniques that includes in vitro and in vivo electrophysiological, optogenetic, imaging, anatomical, molecular, and pharmacological techniques to determine the underlying mechanisms of normal and pathological network activity. Ultimately, his team’s research aims to develop evidence-based targets for therapeutic treatments of epilepsy and other brain disorders.

Contact Information:

Email: sanghunlee@uams.edu
Office: Biomedical Research Building II – Room 341A-2
Phone: 501-686-7379
Fax: 501-686-7850
Mailing Address: University of Arkansas for Medical Sciences
4301 W. Markham, Slot #585
Little Rock, AR 72205
Curriculum Vitae: Sang-Hun Lee CV 

Selected Publications:

Lee S.H.*, Dudok B, Parihar V.K., Jung K.M., Miklós Z., Kang Y.J., Maroso M., Alexander A.L., Nelson G.A., Piomelli D., Katona I., Limoli C.L., and Soltesz I. (2016) Neurophysiology of space travel: Energetic solar particles cause cell type-specific plasticity of neurotransmission, Brain Structure & Function DOI: 10.1007/s00429-016-1345-3. *Corresponding author.

Armstrong C., Wang J., Lee S.Y., Broderick J., Bezaire M., Lee S.H., and Soltesz I. (2016) Target-selectivity of parvalbumin-positive interneurons in layer II of medial entorhinal cortex in normal and epileptic animals, Hippocampus 26:779-793.

Maroso M., Szabo G.G., Kim H.K., Alexander A., Bui A., Lee S.H., Lutz B., and Soltesz I. (2016) Cannabinoid control of learning and memory through HCN channels, Neuron 89: 1059-1073.
♦Highlighted in Previews, Neuron, 89: 889-891.

Lee S.H.*, Ledri M.*, Tóth B.*, Marchionni I., Henstridge C. M., Dudok B., Kenesei K., Barna L., Szabó S.I., Renkecz T., and et al. (2015) Multiple forms of endocannabinoid and endovanilloid signaling regulate the tonic control of GABA release, Journal of Neuroscience 35: 10039-10057. *These authors contributed equally to this work.
♦Evaluated by Faculty of 1000: http://f1000.com/prime/725624269

Soltesz I., Alger B., Kano M., Lee S.H., Lovinger D., Ohno-Shosaku T., and Watanabe M. (2015) Weeding out bad waves: Towards selective cannabinoid circuit control in epilepsy, Nature Reviews Neuroscience 16: 264-277.
♦Evaluated by Faculty of 1000: http://f1000.com/prime/725443754

Dudok B., Barna L., Szabó S., Szabadits E., Pintér B., Woodhams S.G., Henstridge C.M., Balla G.Y., Nyilas R., Varga C., Lee S.H., and et al. (2015) Cell type-specific STORM superresolution imaging reveals nanoscale organization of cannabinoid signaling at hippocampal GABAergic synapses, Nature Neuroscience 18: 75-86.
♦Evaluated by Faculty of 1000: http://f1000.com/prime/725267801

Lee S.H.*, Marchionni I.*, Bezaire M., Varga C., Danielson N., Lovett-Barron M., Losonczy A., and Soltesz, I. (2014) Parvalbumin-positive basket cells differentiate among hippocampal pyramidal cells, Neuron 82: 1129-1244. *These authors contributed equally to this work.
♦Evaluated by Faculty of 1000: http://f1000.com/prime/718391812
♦Highlighted with a video abstract: https://www.youtube.com/watch?v=KiVdY6XZAL0

Ma R., Cui H., Lee S.H., Anastasio T.J., and Malpeli J.G. (2013) Predictive encoding of moving target trajectory by neurons in the parabigeminal nucleus, Journal of Neurophysiology 109: 2029-2043.

Krook-Magnuson E., Varga C., Lee S.H., and Soltesz I. (2012) New dimensions of interneuronal specialization unmasked by principal cell heterogeneity, Trends in Neurosciences 35: 175-184.

Krook-Magnuson E., Luu L., Lee S.H.,Varga C., and Soltesz I. (2011) Ivy and neurogliaform interneurons are a major target of µ opioid receptor modulation, Journal of Neuroscience 31:14861-14870.

Lee S.H. and Soltesz I. (2011) Requirement for CB1 but not GABAB receptors in the cholecystokinin mediated inhibition of GABA release from cholecystokinin expressing basket cells, Journal of Physiology 589:891-902

Földy C., Lee S.H., Morgan R.J., and Soltesz I. (2010) Regulation of fast-spiking basket cell synapses by the chloride channel ClC2, Nature Neuroscience 13: 1047-1049.
♦Highlighted in News and Views, Nature Neuroscience, 13: 1043-1044.

Lee S.H., Földy C., and Soltesz I. (2010) Distinct endocannabinoid control of GABA release at perisomatic and dendritic synapses in the hippocampus, Journal of Neuroscience 30: 7993-8000.

Lee S.H.*, Govindaiah G.*, and Cox C.L. (2010) Selective excitatory actions of DNQX and CNQX in rat thalamic neurons, Journal of Neurophysiology 103: 1728-1734. *These authors contributed equally to this work.

Lee Y., Park E., Lee S.H., Kim Y.W. and Lee C.J. (2009) Ginsenoside Rg1 reduced spontaneous epileptiform discharges and behavioral seizure in the zebrafish, Journal of Ginseng Research 33(1): 48-54.

Lee S.H. and Cox C.L. (2008) Excitatory actions of peptide histidine isoleucine on thalamic relay neurons, Neuropharmacology 55: 1329-1339.

Lee S.H., Govindaiah G., and Cox C.L. (2007) Heterogeneity of firing properties among rat thalamic reticular nucleus neurons, Journal of Physiology 582: 195-208.

Lee S.H. and Cox C.L. (2006) Excitatory actions of vasoactive intestinal peptide on mouse thalamocortical neurons are mediated by VPAC2 receptors, Journal of Neurophysiology 96: 858-871.

Lee S.H. and Cox C.L. (2003) Vasoactive intestinal peptide selectively depolarizes thalamic relay neurons and attenuates intrathalamic rhythmic activity, Journal of Neurophysiology 90: 1224-1234.

Yang S.C, Lee S.H., Park J.K., Jung M.W., and Lee C.J. (2000) Ginsenoside Rb1 reduces spontaneous bursting activity in thalamocortical slices of the rat, Journal of Ginseng Research 24(3): 134-137.

Lee S.H., Yang S.C., Park J.K., Jung M.W., and Lee C.J. (2000) Reduction of electrically evoked neural activity by ginseng saponin in rat hippocampal slices, Biological & Pharmaceutical Bulletin 23(4): 411-414.

Link to Dr. Lee’s PubMed publications:

http://www.ncbi.nlm.nih.gov/myncbi/browse/collection/45896994/?sort=date&direction=ascending